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Test 2 2006 - 1 Test#2 IPPH 362 Name Seat I Short answers...

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1 Test #2 IPPH 362 Name_______________ 10/04/06 Seat ________________ I. Short answers. Each answer is worth 2 points. No partial credit. 1. Matching 1. eliminated mainly by excretion 2. eliminated mainly by metabolism 3. eliminated mainly in the feces 4. eliminated mainly in the breath 5. stored in the bones ________ A. ketoconazole ________ B. prednisolone ________ C. ampicillin 2. Matching 1. time to peak 2. peak concentration 3. area under the curve 4. time to D u 5. D u ________ A. Best blood level parameter to monitor rate of absorption ________ B. Blood level parameter that is affected by BOTH rate of absorption and extent of absorption ________ C. Best urinary excretion parameter to monitor the extent of absorption
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2 3. Matching 1. gelatin 2. magnesium stearate 3. sodium lauryl sulfate 4. starch 5. Tween 80 _________ A. swells when in contact with water _________ B. hydrophilic lubricating agent _________ C. slows the rate of dissolution of the drug 4. Match the terms (D, S, h, C s , C g ) in the dissolution equation to the following observations. ________ A. Increase the rate of dissolution by use of sodium para-aminosalicylate rather than para-aminosalicylic acid. ________ B. Increase the rate of dissolution by drinking a glass of water with the tablet. ________ C. Increase the rate of dissolution of a hydrophobic drug by using gelatin as the granulating agent. ________ D. Increase the rate of dissolution of a hydrophobic drug by using Tween 80, a wetting agent, as an excipient in the formulation.
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