test 2 2008 test - Test 2 IPPH 362 Name 10/8/08 Seat l....

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 8
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Test 2 IPPH 362 Name 10/8/08 Seat l. Short Answers. Each answer is worth 2 points. No partial credit. 1. Draw the expected graphs A. Blood concentration vs. time following an intravenous dose of a drug that is excreted and metabolized but does not distribute to the tissues. 19533 \ M €— . . . B. Blood concentration vsf‘i‘ime followmg an intravenous dose of a drug that IS excreted, metabolized, and distributed to the tissues. I 05136 In . . . . C. Blood concentration time following a rectal supposflory containing a drug that IS excreted and metabolized. Tlhm. D. Blood concentration vs. time following an intramuscular injection of a drug that is excreted and metabolized. TIM. 2. Draw the expected curve in comparison to the reference curve. A. A tablet that contains 50% of the starch that is in the reference tablet. be TIML B. A tablet that contains a polymer that forms a non-absorbable complex with 50% of the drug. 3. Indicate how each drug leaves the body after an oral dose. unchanged drug in urine drug metabolites in urine unchanged drug in feces drug metabolites in feces unchanged drug in breath .U'PWNT‘ A. ampicillin B. ethanol C. hydrocortisone D. ketaconazole E. nitroglycerin 4. Circle the correct answer A. The fastest, slowest reaction in a series of reactions is the rate limiting step. B. Drug metabolites are usually lipid; water soluble. C. Oral dose adjustment is based on the assumption that the concentration of drug in the target tissue is directly proportional. egual, inversely proportional, n_ot related to the concentration of drug in the blood. D. Dissolution rate studies fl, are not dependable indicators of bioavailability. 5. Bioavailability studies may monitor a pharmacological response by measuring a changein 6. The best parameter from the blood concentration vs. time curve to use to evaluate the extent of absorption is the 7. The best parameter from a cumulative urinary excretion vs. time curve to evaluate the rate of absorption is the 8. Indicate the term in the dissolution equation that is affected by the following elements in the formulation of a tablet of a hydrophobic drug. 5 9 WPWNe oomzc A. Use of starch B. Use of magnesium stearate C. Use of micro-crystals of the drug D. Use of the salt form of the drug E. Use of gelatin F. Use of Tween 80 G. Drink a glass of water with the tablet H. Use the crystal form of the drug having the largest average intermolecular distance I. Dimensions of the drug molecule 9. Briefly explain why a coated tablet has a higher potential for interference with oral bioavailability than a suspension. 10. The prodrug clindamycin palmitate produces the active drug in the GI tract due to: 11. Why is the peak concentration of methotrexate delayed when taken with breakfast in comparison to a fasting stomach? (see Fig. 2) 12. Why is the peak concentration of atenolol delayed when co-administered with propantheline? (see Fig. 6) 13. A drug having a volume of distribution of 12 liters is expected to be more lipid soluble than water soluble. (true, false) ll. Problems. Each answer is worth 4 points. No partial credit. 14. What intravenous dose of tobramycin would you administer every 8 hours to a 40 year old male patient who has a serious but not life threatening infection? The patient weighs 220 lbs. Lab tests show that his creatinine clearance rate is 60 mL/min. m9 15. What is the total clearance rate of a drug that has a volume of distribution of 60 liters and a rate constant of excretion of 0.3 hr'1 and a rate constant of metabolism of 0.6 hr"? The drug is eliminated by excretion and metabolism. liters/hour 16. The total cumulative amount of drug excreted following a 250 mg intravenous dose was 100 mg. The drug is eliminated by excretion and metabolism. The rate constant for elimination is 0.15 hr". What are the rate constants for excretion and metabolism? k6 = hour'1 km = hour '1 17. It was found that 60 mg of drug were excreted during the first 8 hours after a 100 mg intravenous dose of a drug that is only eliminated by excretion. What is the rate constant for excretion? hour' 18. A drug is eliminated by excretion (ke = 0.10 hr '1) and metabolism (km = 0.07 hr“). What is the half life of the drug? hours 19. A patient who is taking the drug in question 18 experiences complete kidney failure. What is the half life of the drug in the patient? hours 20. A drug that is totally eliminated by excretion has 20 mg remaining in the body 12 hours after an intravenous dose of 100 mg. What is the rate constant for elimination? hour' 21. An intravenous dose of 20 mg produces an initial blood level of 2 ug/mL. A blood sample taken 8 hours after the dose had a drug concentration of 0.8 uglmL. A. What is the rate constant for the elimination of this drug? (4 points) hour '1 B. What is the volume of distribution of this drug? (4 points) liters ...
View Full Document

This note was uploaded on 02/12/2010 for the course IPPH 362 taught by Professor Hem during the Spring '08 term at Purdue University-West Lafayette.

Page1 / 8

test 2 2008 test - Test 2 IPPH 362 Name 10/8/08 Seat l....

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online