Critique FINAL

Critique FINAL - Critique of a Scientific Article James...

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Critique of a Scientific Article James Marsh (04138848) 1 Improved neovascularisation and wound repair by targeting human basic fibroblast growth factor (bFGF) to fibrin. Zhao, W., Han, Q., Lin, H., Gao, Y., Sun, W., Zhao, Y., Wang, B., Chen, B., Xiao, Z., and Dai, J. Article Summary This paper proposes a novel method for the improved formation of new blood vessels (neovascularisation) during wound repair by targeting basic fibroblast growth factor (bFGF), a naturally produced angiogenic factor, to fibrin (a key component of plasma clots at wound sites) (Zhao et al. , 2009). This is achieved by the fusion of bFGF to the Kringle1 domain of plasminogen, a peptide with a high affinity for fibrin, allowing site-specific delivery of the recombinant protein (K1bFGF) to the fibrin scaffold. The authors also extended this approach by applying of K1bFGF to cases where plasma clots did not exist through the development of a fibrin-scaffold/K1bFGF system (Zhao et al. , 2008). The results indicated that the recombinant K1bFGF bound fibrin with a greater affinity than bFGF alone, and was also retained for longer in a fibrin scaffold than bFGF (Breen et al. , 2009). Furthermore, it was demonstrated that fibrin containing K1bFGF considerably enhanced neovascularisation and that fibrin scaffolds containing K1bFGF had more proliferating cells than control groups (Breen et al. , 2009). Title The title precisely states the subject of the paper and adequately reflects the content of the work. There are no “jargon” or “buzz” words that are not directly relevant to the subject matter and it succeeds in stimulating the interest of the reader. However, it is suggested that “targeted therapy” be included in the title (and key words). Targeted therapy is garnering increased attention as a novel approach to drug delivery (Strieter et al. , 1995; Sawyers, 2004), where a drug is specifically targeted to a therapeutic site thus reducing any adverse effects on surrounding tissues (Breen et al. , 2009). This concept is referred to in the opening sentence of the abstract and is outlined further in the introduction, indicating its clear relevance and importance to the research question, warranting its inclusion in the title (and key words). For this reason it is suggested that the title be altered to read: “Using targeted therapy to improve neovascularisation and wound repair by attaching human basic fibroblast growth factor (bFGF) to fibrin.” Abstract The abstract is well-structured, beginning with two sentences of background information followed by a statement of the research question being proposed and what was done to answer it. The statement of purpose matches the one in the introduction, and it accurately summarises the complete article by providing the highlights from the introduction, methods, results, and discussion. Only the most important findings that specifically address the hypothesis are presented, in a logical order, and it makes sense when read in isolation. The authors have produced a clear abstract that provides just enough detail to
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This note was uploaded on 02/14/2010 for the course SC 01 taught by Professor Dickens during the Three '10 term at Queensland Tech.

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Critique FINAL - Critique of a Scientific Article James...

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