Critique of a Scientific Article
James Marsh (04138848)
Improved neovascularisation and wound repair by
targeting human basic fibroblast growth factor (bFGF) to fibrin.
Zhao, W., Han, Q., Lin, H., Gao, Y., Sun, W., Zhao, Y., Wang, B., Chen, B., Xiao, Z., and Dai, J.
This paper proposes a novel method for the
improved formation of new blood vessels
(neovascularisation) during wound repair by targeting basic fibroblast growth factor (bFGF), a naturally
produced angiogenic factor, to fibrin (a key component of plasma clots at wound sites) (Zhao
This is achieved by the fusion of bFGF to the Kringle1 domain of plasminogen, a peptide with a
high affinity for fibrin, allowing site-specific delivery of the recombinant protein (K1bFGF) to the fibrin
The authors also extended this approach by applying of K1bFGF to cases where plasma clots
did not exist through the development of a fibrin-scaffold/K1bFGF system (Zhao
indicated that the recombinant K1bFGF bound fibrin with a greater affinity than bFGF alone, and was also
retained for longer in a fibrin scaffold than bFGF (Breen
Furthermore, it was demonstrated
that fibrin containing K1bFGF considerably enhanced neovascularisation and that fibrin scaffolds
containing K1bFGF had more proliferating cells than control groups (Breen
The title precisely states the subject of the paper and adequately reflects the content of the work.
are no “jargon” or “buzz” words that are not directly relevant to the subject matter and it succeeds in
stimulating the interest of the reader.
However, it is suggested that “targeted therapy” be included in the
title (and key words).
Targeted therapy is garnering increased attention as a novel approach to drug
, 1995; Sawyers, 2004), where a drug is specifically targeted to a therapeutic site
thus reducing any adverse effects on surrounding tissues (Breen
This concept is referred to
in the opening sentence of the abstract and is outlined further in the introduction, indicating its clear
relevance and importance to the research question, warranting its inclusion in the title (and key words).
For this reason it is suggested that the title be altered to read:
“Using targeted therapy to improve
neovascularisation and wound repair by attaching human basic fibroblast growth factor (bFGF) to fibrin.”
The abstract is well-structured, beginning with two sentences of background information followed by a
statement of the research question being proposed and what was done to answer it.
The statement of
purpose matches the one in the introduction, and it accurately summarises the complete article by
providing the highlights from the introduction, methods, results, and discussion.
Only the most important
findings that specifically address the hypothesis are presented, in a logical order, and it makes sense
when read in isolation.
The authors have produced a clear abstract that provides just enough detail to