Assignment%2033

Assignment%2033 - UNIVERSITY OF COLORADO AT BOULDER...

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U NIVERSITY OF C OLORADO AT B OULDER Department of Integrative Physiology IPHY 4720 – Neurophysiology Assignment 3 You may find the following online simulation useful when calculating the GHK equation: http://www.nernstgoldman.physiology.arizona.edu/ . The simulator also shows ion concentrations and this can be a useful tool in helping you to visualize what happens when a variable is altered. However, make sure that you also know how to solve the equation with your calculator. 1. Given the following concentrations inside and outside the giant squid axon: in (mM) out (mM) K + 400 20 Na + 50 440 Cl 52 560 The relative permeabilities are: P K : P Na : P Cl = 1 : 0.04 : 0.45 a. Use the Goldman equation to determine how much does Cl contribute to V r ? b. Explain your answer to part a given that P Cl is high and E Cl = –60 mV. c. Why is V r negative when [K + ] i is so high? 2. Which statements about the patch-clamp technique are correct? a.
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Assignment%2033 - UNIVERSITY OF COLORADO AT BOULDER...

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