Chapter%2001Notes0

Chapter%2001Notes0 - Course Content Chapter 1: Basic...

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Course Content Chapter 1: Basic Concepts in Immunology Chapter 2: Innate Immunity Chapter 3/4: Antigen Recognition by T & B cells Chapter 5: Antigen Presentation to T cells Chapter 7: Development & Survival of Lymphocytes Chapter 8: T Cell-Mediated Immunity Chapter 9: Humoral Immune Response Chapter 10: Dynamics of Adaptive Immunity Chapter 11: Mucosal Immunity
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Janeway’s Immunobiology Seventh Edition Chapter 1 Basic Concepts in Immunology Copyright © Garland Science 2008 Murphy • Travers • Walport
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Chapter 1: Basic Concepts in  Immunology Founding Fathers Innate versus Acquired Immune Cells  Lymphoid Tissue Anatomy The Antigen Diversity Problem Clonal Selection Hypothesis:  Clonal deletion; Clonal selection; Lymphocyte Antigen Recognition: T cell versus B cell Antigen Presentation: MHC I and MHC II Lymphocyte Activation: Effector Functions
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Figure 1-1 Founding Fathers of Immunology Edward Jenner 1796 Cowpox vaccinia prevented small pox
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Immune System Innate Acquired humoral cellular 1. Quick 2. Non-specific 3. No immunological memory 4. Phylogenetically old Slow Extremely specific Immunological memory Phylogenetically newer
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Immune Cells: Cellular Heterogeneity Stages of Differentiation
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Immune Cells
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Figure 1-3 part 2 of 4 Immune Cells
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Figure 1-3 part 3 of 4 Immune Cells
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Immune Cells
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Immune Cells: Innate Immunity
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Chapter 1: Basic Concepts in  Immunology Founding Fathers Innate versus Acquired Immune Cells  Lymphoid Tissue Anatomy The Antigen Diversity Problem Clonal Selection Hypothesis:  Clonal deletion; Clonal selection; Lymphocyte Antigen Recognition: T cell versus B cell Antigen Presentation: MHC I and MHC II Lymphocyte Activation: Effector Functions
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Lymph Vessel System
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1. Return fluid/proteins to blood 2. Fat absorption at small intestine return to blood 3. Capture and destroy foreign pathogens 4. Review: Filtration/Absorption pp. 517-520 4thed. Silverthorn Immune/Lymphatic system
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Lymph Circulation Draining Lymph Node One-way valves Afferent Lymphatic vessels High endothelial venules (HEV)
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Chapter%2001Notes0 - Course Content Chapter 1: Basic...

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