MICRO 4.6.docx - Bio 221 Study Guide Lesson 4-6...

Bio 221 Study Guide
Lesson 4-6 Antimicrobial Drug Resistance
Preparation:
● Read Section 14.5 Drug Resistance pp. 641-646
● Read Section 14.6 Testing the Effectiveness of Antimicrobials pp. 647-651
Study Questions: Be able to answer the following.
Drug Resistance
● List the factors that have accelerated the evolution of resistance of antimicrobial
drugs.
.
● Describe the possible ways that microbes undergo the genetic changes to
become drug resistant.
● Describe the cellular drug resistance mechanisms used by microbes.

lincosamides can also occur due to enzymatic inactivation of the drug or modification.
Prevention of Cellular Uptake or Efflux
Microbes may develop resistance mechanisms that involve inhibiting the accumulation of an antimicrobial drug,
which then prevents the drug from reaching its cellular target. This strategy is common among gram-negative