compressed LCMS Proteomics

compressed LCMS Proteomics - Compression of LC/MS Proteomic...

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Compression of LC/MS Proteomic Data Agnieszka C. Miguel John F. Keane Jeffrey Whiteaker Heidi Zhang Amanda Paulovich Electrical and Computer Engineering, Seattle University Fred Hutchinson Cancer Research Center, Seattle, WA The unrelenting growth of liquid chromatography-mass spectrometry (LC-MS) based proteomic data to gigabytes per sample and terabytes per experiment motivates this inves- tigation into compression methods suited to MS signal sources. Proteomics, the study of the protein composition of biological entities, is expected to have a significant impact on science and medicine. MS is an enabling technology for proteomics because it can simul- taneously indicate both peptide sequences and abundances for hundreds of proteins from a given sample. Compression is needed to facilitate storage, searching, archiving, retrieval, and communication of proteomic MS data. Most information provided by a mass spec- trometer is in the mass to charge ratio (m/z) and intensity measurements for the detected
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This note was uploaded on 02/16/2010 for the course CHEM 589 taught by Professor -1 during the Fall '02 term at Penn State.

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