Compression of LC/MS Proteomic Data ∗ Agnieszka C. Miguel † John F. Keane ‡ Jeffrey Whiteaker ‡ Heidi Zhang ‡ Amanda Paulovich ‡ † Electrical and Computer Engineering, Seattle University ‡ Fred Hutchinson Cancer Research Center, Seattle, WA The unrelenting growth of liquid chromatography-mass spectrometry (LC-MS) based proteomic data to gigabytes per sample and terabytes per experiment motivates this inves-tigation into compression methods suited to MS signal sources. Proteomics, the study of the protein composition of biological entities, is expected to have a signiﬁcant impact on science and medicine. MS is an enabling technology for proteomics because it can simul-taneously indicate both peptide sequences and abundances for hundreds of proteins from a given sample. Compression is needed to facilitate storage, searching, archiving, retrieval, and communication of proteomic MS data. Most information provided by a mass spec-trometer is in the mass to charge ratio (m/z) and intensity measurements for the detected
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This note was uploaded on 02/16/2010 for the course CHEM 589 taught by Professor -1 during the Fall '02 term at Penn State.