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Exam4Notes - Chapter 11 The Citric Acid Cycle Learning...

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Chapter 11 The Citric Acid Cycle Learning Objectives Entry of Pyruvate into TCA cycle Roles of Coenzymes Steps of the TCA cycle Regulation Multiple roles of TCA Cycle in Catabolism & Anabolism Details Entry of Pyruvate to Cycle (pyruvate dehydrogenase complex) Lots of foods (both dietary and stored) yield pyruvate eg dietary proteins yield amino acids which break down to pyruvate eg stored polysaccharides (glycogen) and stored fats (neutral fats) can yield pyruvate. Pyruvate formed in the cytoplasm has to be transported into mitochondria for TCA Cycle use. Pyruvate Dehydrogenase Complex Overall reaction Pyruvate + NAD + CoASH gives Acetyl-CoA +CO 2 + NADH Three types of enzymes Know the reactions for each of the enymes and the cofactors involved. Know how reduced lipoamide is re=oxidised How is FAD involved? Control: Roles of Acetyl-CoA and NADH
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TCA Cycle Proper Know each of 8 reactions including substrates, products coenzymes etc (see p348) Know NADH production sites Know GTP production site Know FADH2 (QH2) production site Control of cycle (p358) Cyclic versus linear pathways TCA Cycle for biosynthesis TCA Cycle Anaplerotic reactions Involvement of glutamate dehydrogenase and transaminases
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