Lecture01PDF - MCB 141 Developmental Biology Welcome to MCB...

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Unformatted text preview: MCB 141 Developmental Biology Welcome to MCB 141: Developmental Biology Instructors: Nipam Patel John Gerhart Richard Harland GSIs: Teresa Lee John Young Class website: http://mcb.berkeley.edu/courses/mcb141/ (or just Google MCB 141 Berkeley) Prerequisites: 102 or C100A; Biology 1A, 1AL, and 1B; Lecture #1 Jan. 19, 2010 110 or 130 recommended Lectures Tuesday and Thursday 11:10 - 12:30 155 Donner Textbook: Scott Gilbert, Developmental Biology 8th edition This book is recommended, not required All information from the lecture takes precedence over what is in the text book. Class website: http://mcb.berkeley.edu/courses/mcb141/ class website includes link to online textbook companion (8th edition) and the 6th edition of the textbook Discussion Sections: Section 103 Tue 1:00 - 2:00 130 Wheeler (Teresa) Section 101 Wed 2:00 - 3:00 182 Dwinelle (John) Section 102 Wed 3:00 - 4:00 122 Wheeler (Teresa) Section 104 Thur 1:00 - 2:00 130 Wheeler (John) 1 Class website: http://mcb.berkeley.edu/courses/mcb141/ Website will have all handouts, old exams, problem sets, course policies, lecture and exam schedule, etc. Grading: 500 possible points: each midterm is worth 100 points; the final will consist of a midterm covering the final third of the course (100 pts) and a cumulative section covering the entire course (100 pts); the final 100 pts will be assigned for participation in section. Nipam H. Patel MCB and IB 519A LSA (enter through door marked 515 and turn left once inside the lab). Email: nipam@berkeley.edu Office hours: Wednesdays 3:30-5:00 PM LSA 519A or by appointment Lecture Topics Referenced Textbook: Gilbert, 8th edition First third of the course: development of Drosophila Lect #1, Jan 19 Overview of principles I. (Chapters 1 and 5) Lect #2, Jan 21 Lect #3, Jan 26 Overview of principles II. Drosophila embryogenesis. Dorsalventral patterning. (pg. 253-266, Chapter 9) Lect #4, Jan 28 Segmentation I (pg. 266-283, Chapter 9) Lect #7, Feb 9 Lect #8, Feb 11 TBA Lect #5, Feb 2 Lect #6, Feb 4 Segmentation II Homeosis I (pg. 283-290, Chapter 9; Chapter 9 and Chapter 11 of Evolution [on reserve at Koshland Biosciences Library]) Homeosis II Homeosis III & Wing Patterning Review and summary PDFs of lectures will be available at the course website within a day after each lecture Midterm I: Tuesday Feb. 16 11:10-12:30. Room TBA. 2 What is Developmental Biology? The field of biological science that tries to understand how we go from a fertilized egg to an adult animal or plant (and then back again). . 3 Key Points: 1) Differentiation - go from a single cell to many different types of cells, each containing unique contents. 2) Morphogenesis - put cells into the right position and organize them to make functional organs. 3) Growth - Control cell number and size to control the the size of organs and the organism. 4) Reproduction - make sure the organism can produce offspring like itself. 5) Evolution - development evolves to make new forms (within species and in creating new species). 6) Environment - development integrates with the environment. 4 5 Approaches: 1) Anatomical - describe embryogenesis 2) Experimental - manipulate the embryo by cutting, grafting, etc. 3) Genetic - isolate mutations that change development. Approaches: 1) Anatomical - describe embryogenesis 2) Experimental - manipulate the embryo by cutting, grafting, etc. 3) Genetic - isolate mutations that change development. 6 7 8 Parhyale hawaiensis 9 Approaches: 1) Anatomical - describe embryogenesis 2) Experimental - manipulate the embryo by cutting, grafting, etc. 3) Genetic - isolate mutations that change development. Approaches: 1) Anatomical - describe embryogenesis 2) Experimental - manipulate the embryo by cutting, grafting, etc. 3) Genetic - isolate mutations that change development. 10 11 ...
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