Dernburg_Lecture7_R_Q - 3 The drug taxol acts to a block...

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Dernburg Lecture 7 – Microtubules Friday, February 12, 2010 Reading: Lodish, Chapter 18 Please read the Introduction and sections 18.1-18.4 (pp. 757-777). I am not planning to talk about cilia or flagella (section 18.5) or intermediate filaments (section 18.7). Next week we will talk about Mitosis and Meiosis, which is partially covered in Section 18.6, so feel free to read ahead. Chapter 18 – Microtubules Multiple-choice questions may have one or more correct answers. Circle ALL that apply. 1. A microtubule protofilament is formed by the a. lateral association of γ -tubulin subunits. b. head-to-tail association of γ -tubulin subunits. c. lateral association of tubulin dimers. d. head-to-tail association of tubulin dimers. e. self-association of GTP-bound tubulin 2. Growing microtubule ends are normally stabilized by a. a GDP cap. b. a GTP cap. c. phosphorylation of tubulin subunits. d. γ -tubulin. e. catastrophe factors
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Unformatted text preview: 3. The drug taxol acts to a. block microtubule assembly. b. promote microtubule assembly. c. promote cell division. d. sever microtubules. e. inhibit cell proliferation 4. Microtubule assembly in a test tube requires a. microtubule-associated proteins. b. incubation at 4 ° C c. GMPPCP d. a tubulin concentration in excess of the Cc e. ATP 5. In cells, the γ-tubulin ring complex is primarily found a. in the hollow core of the microtubule b. at the microtubule (−) end c. at the microtubule (+) end d. along the seam of the microtubule e. within the pericentriolar material 6. The region of a kinesin protein that interacts with the motor’s cellular cargo is the a. head domain b. neck domain c. tail domain d. rod domain e. light chain 7. Cytosolic dynein is linked to vesicles and chromosomes via a. its head domain b. its stalk domain c. dynactin d. kinesin I e. dynamin...
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Dernburg_Lecture7_R_Q - 3 The drug taxol acts to a block...

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