Lecture _1 - Jan. 20 - Spring 2010 Spring 2009 (4 Units)...

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How do viruses do what they do? Instructors: Britt Glaunsinger & Andy Jackson Learn all about the exciting feld oF virology, including how viruses multiply, viral contributions to human health & disease, cross-kingdom virology, current viral threats, career opportunities, and more!! Text Spring 2010 MWF 2-3 PM, Th 5:30-7 PM
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bacteriophage attaced to a cell wall VIRUSES coronavirus are cool. ..
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They outnumber all other forms of life by > 1 order of magnitude. Every living organism studied to date has at least 1 virus associated with it! Viral presence on this planet is all encompassing, and every sequenced organism has components of its genome of viral origin. Viruses are integral players in the evolution of life! >10 24 infections per second (10 9 =1 billion) Placed end to end, they would stretch over 200 million light years. Viruses are the most abundant biological entities on Earth!! VIRUSES: WHY SHOULD YOU CARE??
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Are Viruses Alive? Maybe the more important question is to what extent do they play a role in the movement and molding of life as we perceive it today? That depends on how you defne liFe. .. By classical defnition, no. They do not respire They do not move They do not grow They are incapable oF energy production They are ‘inert’ unless associated with another living organism BUT. .. They most certainly reproduce And evolve And have an individual evolutionary history And are independent in that they are not limited to a single organism or even species as host
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Viruses Cause a Multitude of Illnesses The common cold Chicken Pox Cold Sores Flu AIDS Hepatitis Some cancers Ebola SARS Rabies Smallpox and many many more. ..
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8% of human genome is of viral origin! Endogenization = assimilation of viral sequences into host genome, generally by integration into chromosome of germ cells. All thought to be of retroviral origin, until recent discovery of Bornavirus endogenization. .. We are made up of viral sequences!
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Genomes of most plants & animals have ~ 1 million times more genetic information than the viruses that infect them. How Big are Viruses?? -avg. of 20-250 nm (1 nm = 1 billionth of a meter!) Largest virus: Mimivirus of amoeba (750 nm diameter; bigger than the smallest bacteria)
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What are they made of? nucleic acid (RNA or DNA) protein coat sometimes lipid envelope
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There are 4 main morphological virus types: Icosahedral Helical (rod shaped or flamentous) Enveloped Complex single type of subunit stacked around a central axis (the most efFcient way of creating an enclosed robust structure from multiple copies of a single protein)
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Property: Nucleic acid D N A R N A Shape L i n e a r Circular Segmented
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This note was uploaded on 02/16/2010 for the course MCB C 58381 taught by Professor Professorbrittglaunsinger,professorandyjackson during the Spring '10 term at University of California, Berkeley.

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Lecture _1 - Jan. 20 - Spring 2010 Spring 2009 (4 Units)...

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