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Lecture _3 - Jan. 25

Lecture _3 - Jan. 25 - Virus Classication Reading Text...

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Virus Classification Reading: Text Chapt. 3
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Classification provides a rational basis for making testable predictions about biology, replication, transmission, and effects of the virus on the host cell.
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parvovirus adenovirus phycodnavirus mimivirus Tobacco mosaic virus Pseudomonas phage Pf1 Viruses Vary Widely in Particle Size
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Circovirus Lambda phage mimivirus Avg. (+)RNA virus …And in Genome Size • Smallest viruses code for only 2-3 proteins, whereas the largest has >1200! • Viral genomes are very compact; most are coding sequence (in contrast to our own genomes which are mostly noncoding) Virus: 1 protein per ~1,000 nt Us: 1 protein per ~100,000 nt
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RSV How do Viruses Get Their Names?? Diseases viruses are associated with, e.g.: Poxvirus , Hepatitis virus, HIV. Cytopathology occuring during infection, e.g.: Respiratory Syncytial virus, Cytomegalovirus. Site of infection , e.g.: Adenovirus , Rhinovirus, Enterovirus. Places where viruses were found or people who discovered them, e.g.: Epstein-Barr virus, Rous Sarcoma, Rift Valley Fever, Ross River Virus. Biochemical features , e.g.: Retrovirus, Picornavirus. Such names are not useful for orderly classification!!!!
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These naming conventions can lead to confusion later e.g.: viral hepatitis is caused by at least 6 different viruses. * 10-20% of cases of presumed viral hepatitis are still not accounted for.
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Related Viruses May Cause Many Different Diseases HSV Herpes Simplex Virus Cold sores (type 1), Genital lesions (type 2) VZV Varicella Zoster Virus Chicken pox • CMV Cytomegalovirus Mononucleosis
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