Lecture _9 - Cross Kingdom Immunity to Viruses Introduction...

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Unformatted text preview: Cross Kingdom Immunity to Viruses Introduction to Comparative Virology Molecular & Cell Biology 114 Spring, 2010 Peter J. Dailey, Ph.D., MPH Senior Vice President, Research & Development Cepheid Cross Kingdom Immunity to Viruses The Host Defense against Viral Infections Host Defense vs. Virus Offense Cross Kingdom Immunity to Viruses Outline: 1.Introduction 2. Perspective 3. Anti-viral Immunity 1. Intrinsic immunity 2. The Innate Immune Response 3. The Adaptive Immune Response (Humoral and Cell-mediated immunity) Immune Response Immune response probably has the greatest impact on the outcome of infection. In most cases, the virus is cleared completely--complete recovery. In other infections, immune response unable to clear virus completely--virus persists. In a number of infections, the immune response plays a major pathological role in the disease. In general, cellular immunity plays the major role in clearing virus infection whereas humoral immunity protects against re-infection. Innate immunityplants, insects, vertebrates Cross Kingdom Immunity to Viruses Outline: 1. Introduction 2.Perspective 3. Anti-viral Immunity 1. Intrinsic immunity 2. The Innate Immune Response 3. The Adaptive Immune Response (Humoral and cell-mediated immunity) Perspective CASE HISTORY Male, 18 months old Shortness of breath Rapid, shallow breathing Inter-costal retractions Malaise Non-productive cough Fever Perspective Perspective The main problem in the CCU is not therapeutic but diagnostic. If the patients problem can be clearly delineated diagnostically, treatment is relatively straightforward matter. Therapy cannot be appropriate unless related to the correct diagnosis. - Burke A. Cunha (Infectious Diseases in Critical Care Medicine) Pneumonia Sepsis Meningitis/Encephalitis Wound infections CDC Campaign to Prevent Antimicrobial Resistance Source: http://www.cdc.gov/drugresistance/healthcare/ Fact: Appropriate antimicrobial therapy (correct regimen, timing, dosage, route, and duration) saves lives. Diagnose & Treat Infection Effectively: Target the pathogen Preventing Antimicrobial Resistance Source: http://www.cdc.gov/drugresistance/healthcare/ Diagnostic uncertainty is a key driver of drug misuse and overuse, which can lead to increased rates of resistant microbes.. new diagnostic tests will facilitate initiation or withdrawal of antimicrobial therapy soon after onset of symptoms ...molecular diagnostics may increase diagnostic accuracy and enable more prudent antimicrobial drug use in the future . Emerg. Infec. Dis. 11:6 (2005) Antimicrobial Resistance Determinants and Future Control S. Harbarth & M.H. Samore Perspective Typical Approach: The hunt for Infectious Diseases--Pathogen-directed detection Challenges: Target multiple pathogens Specimen collection: invasive, inaccessible, multiple types Sample processing Contaminating normal flora Perspective What if ?.... What if ?...
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This note was uploaded on 02/16/2010 for the course MCB C 58381 taught by Professor Professorbrittglaunsinger,professorandyjackson during the Spring '10 term at University of California, Berkeley.

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Lecture _9 - Cross Kingdom Immunity to Viruses Introduction...

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