Lecture _10 - Host-virus equilibrium Immune evasion by...

Info icon This preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Laurent Coscoy Immune evasion by viruses Viral infections are highly dynamic processes: The virus must replicate and spread to additional host individuals for long- term survival. This is achieved despite a strong antiviral response. Viruses display a broad repertoire of strategies to cope with host defenses. In this co-evolutionary process, there must have been strong selective pressures to maintain both viable hosts and infectious viruses Host-virus equilibrium The Innate and Adaptive immune response to viruses 0 1 2 3 4 5 6 7 8 9 10 IFN-I NK-cells CTL Days after infection Innate Adaptive Innate Immune response: control infection at early stage Adaptive immune response: clear infection at later stages Innate response: Interferon type I (IFN-I) NK, NK-T cells Complement TRIM5 α ……… Adaptive response: CTL B-cells (antibodies) The Innate and Adaptive immune response to viruses Innate (IFN-I, NK) Adaptive (CTL, Ab) Influenza Hepatitis C HIV 0 3 6 9 Days Weeks/Months/years 1 2 3 4 5 6 7 8 9 10 11 12 HSV Passive Mechanisms: - Infection of privileged tissues - Latency - Antigenic variation Active Mechanisms: - Immunomodulatory proteins . More aggressive Mechanisms: - Immunosuppression Different types of evasion strategies Passive Mechanisms: - Infection of privileged tissues - Latency - Antigenic variation Active Mechanisms: - Immunomodulatory proteins . More aggressive Mechanisms: - Immunosuppression Different types of evasion strategies
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2 Herpes Simplex Virus (HSV-1 and 2) Infection of privileged tissues HSV1 and HSV2 are closely related, alpha herpesviruses Large seroprevalence, life long infection: HSV1: 60% of the population infected HSV2: 25% of the population infected HSV type 1 causes cold sores (also called fever blisters) on the lips. spread by kissing HSV type 2 causes sores in the genital area (genital herpes). spread by sexual contact. HSV-1 now accounts for as many as 30% of all genital herpes cases in the U.S Neurones do not express MHC-I molecules Herpes Simplex Virus (HSV-1 and 2) Infection of privileged tissues HSV 1 usually establishes latency in the trigeminal ganglion.
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.
  • Spring '10
  • ProfessorBrittGlaunsinger,ProfessorAndyJackson
  • immunosuppression, Human immunodeficiency virus, Adaptive immune response, antigenic variation, privileged tissues

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern