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Unformatted text preview: 1 MCB 141 Lecture #7 Feb. 09, 2010 For lectures 6 and 7, the suggested textbook (Gilbert) does not contain a good overview. Barton, N.H., Briggs, D.E.G., Eisen, J.A., Goldstein, D.B., Patel, N.H. (2007). Evolution . Cold Spring Harbor Press, New York. pp 287-305 [THESE PAGES ARE ON RESERVE IN THE LIBRARY] Of¡ce hours (NHP; Room LSA 519A) Wed Feb. 10 4 - 5:30 PM Fri Feb. 12 10 - Noon Mon. Feb. 15 3 - 5 PM MIDTERM Tue. Feb 16 11:10 - 12:30 Sample exams are posted at website Mn Mx La T1 T2 T3 A1 A2 A3 A4 A5 A6 A7 A8 Ubx – WT abd-A – Abd-B – Mn Mx La T1 T2 T2 T2 A2 A3 A4 A5 A6 A7 A8 Mn Mx La T1 T2 T3 A1 A1 A1 A1 A5 A6 A7 A8 Mn Mx La T1 T2 T3 A1 A2 A3 A4 A4 A4 A4 A4 In homeotic mutants, still the right number of segments, but the identity of some are transformed to the identity of others. Drosophila (fruit ¢y) Homeotic (Hox) Genes 2 Normal fy Ubx expressed T3 & post. Loss oF Ubx expression From T3 late in development Drosophila (Fruit fy) Mouse Homeotic (Hox) Genes Present in all animals Organized into a cluster Regionally expressed along the anterior-posterior axis oF the embryo Are responsible For regionalization oF the body axis Mn Mx La T1 T2 T3 A1 A2 A3 A4 A5 A6 A7 A8 Ubx – WT abd-A – Abd-B – Mn Mx La T1 T2 T2 T2 A2 A3 A4 A5 A6 A7 A8 Mn Mx La T1 T2 T3 A1 A1 A1 A1 A5 A6 A7 A8 Mn Mx La T1 T2 T3 A1 A2 A3 A4 A4 A4 A4 A4 In homeotic mutants, still the right number oF segments, but...
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This document was uploaded on 02/16/2010.
- Spring '09