2ALecture 14

Coupled transcription and translation in prokaryotes

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Unformatted text preview: UC U A G A A U C No tRNAs recognize UAG! Release factor (protein)recognizes UAG •  Termination NH3+ R1 O CH C NH R2 O CH C NH R3 O CH C •  Termination Bond hydrolysis O H! O C O! R4 CH H! NH Hydrolyzed bond A AG G A A G A U G C C C GC G U UC U A G A A U C Release factor cleaves peptide from tRNA 7 2/9/10 •  Termination Additional Features of Translation mRNA can be read simultaneously by more than one ribosome new peptide •  “Polyribosomal RNA” Ribosome releases mRNA tRNAs, release factor are recycled A single mRNA can produce many copies of a protein. •  Coupled transcription and translation In prokaryotes (bacteria), ribosomes can translate during transcription! no nuclear envelope Protein synthesis can be coupled to protein translocation via signal sequences SRP Signal sequence 3...
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