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BIOL_1005_muscles_2 - Musclesandwork BIOL1005 Fall,2009...

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Muscles and work BIOL 1005 Fall, 2009
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Skeletal muscle cell 1ZW7X2360350569225  
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Muscle contraction ATP is necessary for “cocking” the  myosin head in the proper orientation to  bind to the active site on the actin  filament In this process, ATP is broken into ADP  + Pi, but still bound to the myosin head  at this point
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Muscle contraction After the myosin heads are primed, Ca+ + released from the SR causes a  conformational change in the actin  chain, uncovering the active site from  myosin binding ATP is also required for the reuptake of  Ca++ into the SR
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Muscle contraction The binding of myosin heads to actin  causes a conformational change in the  myosin, “pulling” the actin chain The change in angle causes release of  the bound ADP and Pi “Fresh” ATP can now bind to the  myosin head 
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Muscle contraction Binding of ATP causes the myosin to  release from actin Myosin heads again are cocked, and  will bind to actin as soon as  depolarization sends in more Ca++
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