Lecture19FALL2009FINAL

Lecture19FALL2009FINAL - Undergraduate Research Seminar...

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Undergraduate Research Seminar Series Monday, October 12th from 2:30-3:20 PM In B102 auditorium, Chemical Life and Science Bld . (across the street (Goodwin Ave.) from the Krannert Center) Speaker - Dan Miller Title - Functional Significance of Adult Hippocampal Neurogenesis in Pro-cognitive Effects of Exercise Using a Transgenic Mouse Model to Directly Manipulate Neurogenesis Everyone is invited. I highly recommend you attend if you have any interest in neuroscience or want to see what conducting research as an undergraduate is like.
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MCB 250 Lecture 19 Genetic Code (Conclusion) Mutation, Mutagenesis, DNA Repair
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Text Table 15-1
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tRNAs Recognize Multiple Codons Anticodon: Codon: Watson-Crick Wobble Anticodon: Codon: Anticodon: Codon: Anticodon: Codon: Watson-Crick Wobble UUC and UUU = Phe UUA and UUG = Leu
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The Genetic Code is: Degenerate - more than one codon per amino acid Read 5’ to 3’ Non-overlapping and read in a fixed reading frame, set at translation initiation Universal (almost) - codons mean the same things in nearly all organisms. There are some variations, though, especially in mitochondria.
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Mutation and Mutagenesis Some Terminology Mutant An organism that differs in DNA sequence from the wild type. Mutation A stable, heritable change in the DNA sequence Can be spontaneous or induced Mutagen A physical or chemical agent that induces mutations
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Point Mutations Transition Purine to Purine or Pyrimidine to Pyrimidine e.g. AT to GC Transversion Purine to Pyrimidine or Pyrimidine to Purine e.g. AT to TA Transitions are more common than Transversions Text Fig. 9-1
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Point Mutations - Consequences for Proteins GAG GAA Glu Glu GAG AAG Glu Lys GAG TAG Glu STOP Silent Mutation Missense Mutation Nonsense Mutation
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Insertion/Deletion Mutations THE CAT ATE THE FAT RAT… Wild Type THE CAT AAT ETH EFA TRA T… +1 insertion THE CAT TET HEF ATR AT… -1 deletion Insertions or Deletions of a number of bases that is not divisible by 3 cause a “frameshift”. The frameshift affects the protein product of the gene containing the mutation. There’s no “frame” in DNA or RNA. At
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Lecture19FALL2009FINAL - Undergraduate Research Seminar...

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