Lecture3CMFFall09FINAL - Looking for Clinical Experience...

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Looking for Clinical Experience? Join Carle Foundation Hospital as a volunteer! As a volunteer you will: Gain vital experience needed for any healthcare related field. Interact with patients and nursing staff. Become an important aspect of the area’s leading provider for healthcare and trauma services. Carle strives to serve people through high quality care, medical research and education including: The area’s only Level I Trauma Center A Level III Neonatal Intensive Care Unit 300 Physicians in 50 specialties Apply now online at: http://www.carle.org/volunteering Application Deadline: August 29—No Exceptions Questions? Contact Brian Barnes at [email protected] or by phone at 383-3362
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MCB 250 - Lecture 3 1. pH and charge in biological molecules (conclusion) 1. DNA structure
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Definition of pKa H N + H H H N H O C O OH C O 14 pKa 1 pH % Deprotonated 50 pKa HA H + + A - Ka [H+] [H+]
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Weak Acids and Bases in Biology The pKa is affected by the local environment.
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Ionic Bonds in Proteins are Affected by pH Lysine Aspartate CH 2 -CH 2 -CH 2 -CH 2 -NH 3 + HOOC-CH 2 CH 2 -CH 2 -CH 2 -CH 2 -NH 3 + - OOC-CH 2 CH 2 -CH 2 -CH 2 -CH 2 -NH 2 - OOC-CH 2 pH Attraction? <2 7 >12 No Yes No
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DNA Structure
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Lecture Outline A Brief History of Genetics - Why is DNA a BIG DEAL? DNA Structure DNA is the genetic material Avery, MacLeod, and McCarty Hershey and Chase Structures of bases, nucleosides, and nucleotides B-DNA structure Double helix, strand polarity Base pairing Stacking interactions Major and minor grooves Charge considerations
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A Very Brief History of Genetics (1) From ancient times: like begets like Mendel (1865, rediscovered 1900) Inheritance of some traits can be explained by simple
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Lecture3CMFFall09FINAL - Looking for Clinical Experience...

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