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Unformatted text preview: 300 nm fiber Looped domains Metaphase chromosome Heterochromatin Euchromatin CHAPTER 16 NOTES: Search for genetic material T.H. Morgan 1916 Genes are located on chromosomes Genetic material=? F. Griffith used pathogenic and non-pathogenic bacteria demonstrated transformation Horizontal gene transfer=transformation Avery, McCarty and MacLeod 1944 DNA=transforming agent Hershey and Chase 1952 Bacteriophage work DNA goes into cell not protein Chargaff 1950 A=T C=G Wilkins and Franklin 1951 X-ray crystallography Watson and Crick 1953 Double Helix DNA Replication-Unwind (Helicase)-Stabilize (Single-strand binding protein ssbp)-Correct overwinding (topoisomerase)-Primer Formation (primase)-Add nucleotides (polymerase)-Sliding clamp (protein)-Ligate Okazaki fragments (ligase)-Can DNA polymerase initiate synthesis? No-Primer and Primase needed...
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