Chap5 - Chapter 5 Contr ol of Cell s by Chemi cal Messengers I Receptors A Characteristics of receptors 1 Specificity Ability of receptor to bind

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Chapter 5: Control of Cells by Chemical Messengers I. Receptors A. Characteristics of receptors 1. Specificity : Ability of receptor to bind limited messengers 2. Saturation : Degree to which receptors are occupied 3. Competition : Ability of different molecules with similar structure to combine with same receptor 4. Antagonist : A molecule that competes with a chemical messenger normally present in body for same receptor. 5. Agonist : A chemical messenger that binds to a receptor and triggers cell response 6. Affinity : The strength with which a ligand binds B. Location 1. Plasma membrane 2. Intracellular C. Regulation of Receptors 1. Down regulation 2. Up regulation II. Signal Transduction Pathways A. Receptor Activation: Change in conformation of receptor due to combination with messenger. Initial step leading to ultimate cellular response
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B. Cellular Response can result in changes of: 1. Permeability, transport, or electrical charge 2. Cellular metabolism 3. Secretory activity
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This note was uploaded on 02/17/2010 for the course INTEGRATIV 130 taught by Professor Kregel during the Spring '08 term at University of Iowa.

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Chap5 - Chapter 5 Contr ol of Cell s by Chemi cal Messengers I Receptors A Characteristics of receptors 1 Specificity Ability of receptor to bind

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