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Chap4 - Chapter 4 Movement of Mol ecul es Acr oss Cell...

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Chapter 4: Movement of Molecules Across Cell Membranes Review: Plasma Membranes: Selectively permeability I. Diffusion = Movement of molecules as a result of random thermal motion A. Magnitude and Direction of Diffusion 1. Flux = Amount of material crossing a surface in unit of time Net Flux =Proceeds from regions of high to low conc. 2. Diffusion Equilibrium=Net flux is ? ; 3. Magnitude of net flux dependent on: a. b. c. d. e. B. Diffusion Rate vs Distance C. Diffusion through Membranes Net flux: F = k p A (C o -C i ) Co= concentration outside Ci= concentration inside kp= permeability constant, ease with which molecule is able to move through a given membrane A= membrane surface area D. Diffusion through Lipid Bilayer 1. Major factor limiting diffusion across a membrane 2. Nonpolar molecules have a higher lipid solubility and diffuse through bilayer more readily
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E. Diffusion of Ions through Protein Channels 1. Ions such as Na + , K + , Cl - , and Ca 2+ diffuse across plasma membranes through protein channels 2.
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