lecture12 - BIEN 130: Bioinstrumentation L12 May 7, 2009...

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BIEN 130: Bioinstrumentation L12 May 7, 2009 Hyle Park
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Signal and noise levels The above graph displays measured thickness changes of an axon as a function of time. In this case, any measured change smaller than around 2 microns is unreliable. The SNR of this measurement is ~3. The output from every bioinstrument has limitations on signal versus noise levels. The sensitivity of a system can be characterized by its signal-to-noise ratio -5 -2.5 0 2.5 5 7.5 10 0.0 2.5 5.0 7 .5 1 0.0 12.5 15.0 17.5 20 .0 thicknes change (nm) tim e (m sec)
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Noise types White noise 1/f0 Pink noise 1/f1 Red noise 1/f2 Shot noise Relative intensity noise Other colors of noise Phase noise Environmental noise 60 Hz noise
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Noise types Intensity dependent Shot Relative intensity noise How is noise calculated? standard deviation Frequency dependent Pink (1/f) Red (1/f2) -5 -2.5 0 2.5 5 7.5 10 0.0 2.5 5.0 7 .5 1 0.0 12.5 15.0 17.5 20 .0 thicknes change (nm) tim e (m sec)
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lecture12 - BIEN 130: Bioinstrumentation L12 May 7, 2009...

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