Human Infectious Diseases Lecture 13 1. Describe the innate immune defenses of the respiratory system and ways they can be compromised. Cilia: pathogenic particles propelled outward by the movement of cilia. Compromised by smoking, thick mucus Secretory IgA: binds to pathogens. Compromised by secratory IgA proteases M cells: Phagocytize pathogens and release them to the macrophages below in the submucousa Mucus: thick layer that prevents pathogens from reaching the epithelial cells below. Coughing: expels pathogens out Alveolar macrophages: phagocytize foreign pathogens Compromised by: smoking, drugs, alcohol 2. What areas of the respiratory tract are colonized by normal flora? Which areas have few, if any organisms? Normal flora: nose, throat, mouth Few: lower bronchi and alveoli 3. Define each of the following syndromes and list the etiological agents associated with each. (what are the pathogens that cause these diseases? a.
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