Topic 19 - Topic 19 Study Questions Vronique Smith(CNS a...

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Topic 19 Study Questions Véronique Smith 1. Be able to describe the following anatomical structures in the central nervous system (CNS): a. ventricles of the brain : 4 small interconnected cavities of the brain that develop from a hollow tube in the developing embryo; certain of its lining cells become integrated with the choroid plexuses b. choroid plexuses : infoldings of blood vessels of the pia mater covered by a thin coat of ependymal cells that form tufted projections in to the 3 rd , 4 th , and lateral ventricles and secrete cerebrospinal fluid; supplied by choroidal arteries c. meninges: 3 fibrous membranes that cover the brain and spinal cord 1) dura mater : “hard mother”; tough outermost covering. Most fiberous. Composed of 2 layers 2) arachnoid mater : “spider-web-like mother”; delicate membrane between the dura mater and the subarachnoid space 3) subarachnoid space : filled with cerebrospinal fluid a) lumbar cistern : large subarachnoid space located between the end point of the spinal cord and the end of the dural sac. Spinal fluid pools here so this is the site of CSF sampling 4) pia mater : “tender mother”; inner most membrane. thin and highly vascularized. Extends into the depths of the fissures and depressions of the brain 2. What is cerebrospinal fluid (CSF) ? CSF is the fluid contained in the ventricles of the brain, the subarachnoid space, and the central canal of the spinal cord. How is it formed and circulated? It is formed by the choroid plexus and is circulated through the ventricles into the subarachnoid space and into the central canal. It’s absorbed into the venous system (cerebral venous sinuses). Pools in cisterns. What is the volume and composition of the CSF? Volume = 150mL Rate of production = 550mL/day. What is the volume and composition of the CSF? Composed of untrafiltrate of plama (1/300 amount of protein as plasma). What is its function?. CSF and meninges protect the brain when the head receives a blow. 3. What are the blood-brain and blood-CSF barriers ?. Rate of molecule passage is inversely proportional the size and directly Subarachn oid space Lumbar cistern (arrow should point to number 5)
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proportional to lipid solubility Describe their anatomy and discuss what substances normally penetrate these anatomical barriers . Natural anatomical barriers to prevent bloodborne invastion of brain and
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This note was uploaded on 02/17/2010 for the course BIO 361 taught by Professor Barth during the Fall '09 term at University of Texas.

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Topic 19 - Topic 19 Study Questions Vronique Smith(CNS a...

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