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Topic 20 pathogenesis - Topic 20 Pathogenesis Meningococcal...

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Topic 20 Pathogenesis Transmission via the respiratory Entry via Attachment and colonization Attachment to microvilli of nonciliated columnar epithelial cells by Pili Opc outer membrane proteins (function also as afimbral adhesin) Colonization sIgA1 protease (cleaves sIgA1 at the hinge region creating Fab and Fc fragments and inactivating IgA1 antibodies) Meningococcal Meningitis and Meningococcemia caused by N. Mucous membrane defenses overcome Sec IgA – Fab end binds specifically to the pathogens and the Fc portion binds to the mucous (traps bacteria) MALT – endocytose pathogens and carry them across the membrane to the underlying macrophages, dendritic cells, and T and B lymphocytes that process it (B cells activate humoral defense) Curved structure of the nose – creates turbulent flow that traps bacteria in mucous before going further Mucous – trap pathogens and contribute and prevent attachment to epithelial cells Tight junctions – prevent passage of microbes between the cells
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  • Fall '09
  • columnar epithelial cells, complement pathway phagocytosis, Mucous membrane defenses, complement intravascular coagulation, response Thwart complement

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