Topic 24 pathogenesis - Hepatitis A 1. Enters through...

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Hepatitis A 1. Enters through ingestion and travels down GI tract 3. Pathogen enters blood stream through oropharynx or epithelial lining of intestine Non-envelope structure of virion facilitates entry into blood stream as it makes the virion resistant to inactivation by acids found stomach 4. Pathogen reaches liver where it begins to multiply slowly in hepatocytes: -virion has tissue tropism for liver cells (hepatocytes) 6. Virus produced in the hepatocytes is released into the bile and then into the stool. Shedding of virus occurs Inflammation of the liver results in jaundice Virus evades the MAC complex due to non-envelope structure Pathology: Direct damage to liver tissue as virus multiplies in hepatocytes 2. Following GI tract defenses against virus are overcome: Acidity in the stomach denatures enveloped viruses 5. The following innate immune defenses work on eliminating pathogen: Interferon limits viral replication A. 1) A virus infected cell makes alpha and beta interferon
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This note was uploaded on 02/17/2010 for the course BIO 361 taught by Professor Barth during the Fall '09 term at University of Texas at Austin.

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