Topic 25 pathogenesis - Hepatitis B Virus Pathogenesis...

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Hepatitis B Virus Pathogenesis Acute Hepatitis 1) Transmission & Entry -Blood, Sexual Transmission, All bodily Fluid Transport to hepatocytes 3) Attachment to Hepatocytes -Via HBsAg Enter Hepatocytes 5) Replicate 7) Countering A b Produce excessive HBsAg into blood stream Ab will be occupied b/f reaching the replication site 2) Innate Defense of Blood and Liver -RES -Kupffer Cell Produced by infected cell Binds uninfected cell Anti-viral genome produced When virus enters Degrades genome 6) Humoral Response (Adaptive) Ab neutralize virus Phagocytosed killed Ab fix C’ C3b opsonize Phagocytosed killed Ab neutralize toxins (none here) 8) Cell-Mediated Immunity CTL Inflammation Walls off pathogen to help kill and prevent its spread to other tissues Vasodilation- blood vessels dilate to speed flow blood and phagocytic cells Vasopermeability -Increases permeability to allow rapid flow of immune cells to site of infection
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Topic 25 pathogenesis - Hepatitis B Virus Pathogenesis...

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