Test 3 key - Bio360K Test 3 Name 1) Different effector T...

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Sheet1 Page 1 Bio360K Test 3 Name 1) Different effector T cells are generated in response to bacterial infection. Which subset(s) contributes to antibody production? Please explain the role of the subset(s). (3) TFH stimulates B cell activation with CD40L. Th1 or Th2 cells secret cytokines that regulate antibody class switching. 2) Influenza vaccine is made from inactivated influenza virus. How does the vaccine confer protection against influenza? (3) Vaccine induces long-lived plasma cells that secrete high affinity antibodies for influenza virus. These neutralizing antibodies prevent viral infection. A patient is deficient in complement C3. Will the vaccine induce adequate immunity against influenza in this patient? Why? (3) No. C3d conjugated to antigen ligates BCR with CD19/CD21/CD81 co-receptor. Signal from the co-receptor is needed for optimal B cell activation. 3) Vaccines can be delivered either intravenously or orally. Which method would provide more effective protection from intestinal pathogen? Why? (3) Oral delivery induces immune response in Peyer& s patch. B cell activation in Peyer& s patch generates predominantly IgA+ plasma cells. IgA is secreted onto the mucosal surface to defend against intestinal pathogens. Additionally, memory B cells and plasma cells induced in Peyer/ s patch are distributed in mucosal tissues. The localization facilitates rapid response to intestinal infection. 4) Mouse A is immunized with NP-CGG. (NP is nitrophenol. CGG stands for chicken .-globulin.) Mouse B is immunized with NP-LPS. Which mouse is expected to produce higher affinity antibody for NP? Why? (3) NP-CGG is TD-antigen, while NP-LPS is TI-I antigen. Only TD-antigen leads to affinity maturation. Thus, mouse A will produce higher affinity antibody for NP. 5) Please compare two patients. Patient A is deficient in AID. Patient B is deficient in CD40L. What is their common symptom(s)? Why do they have the symptom(s)? (3) Both AID deficiency and CD40L deficiency prevent antibody class switching and somatic hypermutation. As a result, these patients lack high affinity IgG and IgA to control bacterial infection. What is the difference in their symptom(s)? What is responsible for the difference? (3) CD40L deficient patient also suffers from opportunistic infections. CD40L-CD40 interaction serves as co-stimulation for T cell activation. In the absence of this
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Sheet1 Page 2 1 signal, CD4 T cells are not optimally induced to produce IFN-. . The deficienc-. . The deficiency reduces the capability of macrophages to kill phagocytosed pathogens. 6) A group of mouse is immunized with chicken .-globulin intravenously. You
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Test 3 key - Bio360K Test 3 Name 1) Different effector T...

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