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110509 CAP - 110509 CAP final cumulative but mostly new...

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110509 CAP final: cumulative but mostly new stuff format: one more esasy than midterm NERVE REGENERATION: -Ramon y Cajal -huge difference in vertebrates if injury in PNS vs CNS Periphery -distal segment dies after 24 hrs (no longer electronically excitable) -on proximal end, found that calcium rushes into cell, initiates production of vesicles, and vesicles form plug to seal -growth cone form on proximal end, attempts to find its original target so it can reattatch to distal end, reennervation. Central -when growth cone forms on proximal side, grows out for 1mm then stops, never grows again (aborted outgrowth) -Aguayyo: cut spinal cord, put in a peripheral nerve graph, the peripheral side had the growth outgrowth more than 1mm: it grew through the peripheral graph to the distal side of the CNS nerve -Schwabb: found antibody, IN-1: NogoA -found some growth through NogoA (protein), limited -family of proteins called MAG: OMGP, NOGO are members -found on surface of myelin -these are responsible for inability of CNS to grow more
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