24 - CAP lecture 9/24/09 Fig 12.22- facilitation,...

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CAP lecture 9/24/09 Fig 12.22- facilitation, antifacilitation (defacilitation) -occur b/c of events in presynaptic terminal being stimulated -also called homosynaptic de/facilitation -heterosynaptic de/facilitation -if presynaptic terminal synapses on another presynapse that synapses on postsynapse -if stimulate presynapse #2 (not dir. Connected) BEFORE stimulate presynapse #1, postsynapse, greatly reduced effect of 1. -if stimulate 1 before 2, then 2 will be same as if stimulated 1 alone -why is this so? -decrease in cl- channels, same as homosynaptic -cat: have to fire 2 lots of times before can fire 1, crayfish: has to fire just 1-10 times b/c of postsynaptic delay --instead of presynaptic events, can also get postsynaptic events, ex fig 12.26 --what are ways that postynaptically, can alter postsynaptic cell response to increase or decrease response of postsynaptic cell if presynaptic cell isn’t showing any plasticity -sensitization: increase the response per same presynaptical AP -2 nd messenger effects, on either transmitter receptor channels or voltage
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24 - CAP lecture 9/24/09 Fig 12.22- facilitation,...

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