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Unformatted text preview: formation of more vesicles of neurotransmitter Longer-term mechanisms Second messenger can effect gene expression in the nucleus, causing a more permanent up-regulation of neurotransmitter production The number of synapses between two cells can increase or decrease as a longer term result of conditioning Kandel received the Nobel prize for this work recently 3 Summary: cellular mechanism of learning Learning/conditioning occurs via synaptic plasticity (The Hebbian model) The enzyme Adenyl cyclase requires Ca 2+ from previous action potentials and serotonin from another neuron to make cAMP, which creates more vesicles of neurotransmitter Long-term plasticity involves changes in gene expression: modifying the cAMP pathway and growing more synapses...
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This note was uploaded on 02/21/2010 for the course BIOL 3411 taught by Professor Stephens during the Spring '10 term at Minnesota.
- Spring '10