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Unformatted text preview: formation of more vesicles of neurotransmitter Longer-term mechanisms • Second messenger can effect gene expression in the nucleus, causing a more permanent up-regulation of neurotransmitter production • The number of synapses between two cells can increase or decrease as a longer term result of conditioning • Kandel received the Nobel prize for this work recently 3 Summary: cellular mechanism of learning • Learning/conditioning occurs via synaptic plasticity (The Hebbian model) – The enzyme Adenyl cyclase requires Ca 2+ from previous action potentials and serotonin from another neuron to make cAMP, which creates more vesicles of neurotransmitter • Long-term plasticity involves changes in gene expression: modifying the cAMP pathway and growing more synapses...
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- Spring '10
- Nobel Prize, Donald Hebb, hebbian plasticity, Air Puff Neuron, serotonin enzyme complex