Handout 8

Handout 8 - Handout 8 Fatty Acid Oxidation: Adipocytes: fat...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Handout 8 Fatty Acid Oxidation: Adipocytes : fat cells Perilipin : a protein that coats lipid droplets in adipocytes When glucagon is released from the pancreas to increase blood glucose, glucagon can bind to a receptor on an adipocyte activating PKA. PKA then phosphorylates perilipin thus opening up the ring of perilipin that surrounds the adipocyte. PKA also phosphorylates hormone-sensitive lipase , which breaks down the triglycerides in to Free Fatty Acids (FFA) and a Glycerol . Glycerol is converted to Glycerol-3-Phosphate by Glycerol Kinase and then to DHAP by Glycerol-3-Phosphate Deyhydrogenase. DHAP enters glycolysis. In the cytosol, the FFA undergoes the following reaction: o Fatty acid + CoA + ATP <=> Fatty Acyl-CoA + AMP + PP i The fatty acyl-CoA is transported in to the mitochondria through a Carnitine transport system. o The Fatty Acyl and CoA are separated temporarily and the fatty-acyl group is attached to carnitine by Carnitine Acyl Transferase I o
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 4

Handout 8 - Handout 8 Fatty Acid Oxidation: Adipocytes: fat...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online