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Unformatted text preview: Introduction to Randomized Controlled Trials and Controlled Trials and Intervention Intervention Studies
Barbara Abrams DrPH PH 150A: Introduction to Epidemiology Spring 2010 2010 1 Objectives Objectives
Describe experimental design Describe experimental design List List steps to collect data Describe design options Describ i Discuss Discuss advantages Identify Identify drawbacks and techniques to minimize problems Disease Disease of the day Discuss a published trial Discuss published trial
2 OverviewOverview-Experimental Epidemiology Epidemiology
Experimental epidemiology tests how well an Experimental epidemiology tests how well an intervention intervention prevents an outcome. Exposure (treatment) is assigned by the Exposure (treatment) is assigned by the investigators. investigators. Applied to individuals (Randomized (R Controlled Controlled Trial) or communities (Community Trials) 3 Terminology Synonyms Terminology - Synonyms
Study, trial Study, trial Experimental, Experimental, intervention Cli Clinical, therapeutic th Field, Field, community
(Community trial is a type of field trial) Maskin Masking, blinding 4 Types of Experimental Trials Types of Experimental Trials
test new treatments new combinations of drugs or test new treatments, new combinations of drugs, or
new new approaches to surgery or radiation therapy. Primary or secondary prevention trials (medicines Primary or secondary prevention trials (medicines, vitamins, vaccines, minerals, or lifestyle changes). Diagnostic Diagnostic trials to find better tests/procedures to find better tests/procedures Screening Screening trials. Quality of Life trials (or Supportive Care trials) study Quality of Life trials (or Supportive Care trials) study ways ways to improve comfort and the quality of life for individuals with a chronic illness.
www.fda.gov/ForConsumers/byAudience/ForPatientAdvocates/HIVandAIDSActiv www.fda.gov/ForConsumers/byAudience/ForPatientAdvocates/HIVandAIDSActiv ities/ucm121345.htm
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- Spring '08