1-20-10PeptideHormonePhylogenetics

1-20-10PeptideHormonePhylogenetics - BIOL13100 Biology II...

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Unformatted text preview: BIOL13100 Biology II: Development, Structure, and Function of Organisms January 20, 2010 Dr. Nancy Pelaez Lilly G-224 [email protected] HOTSEAT How many amino acids are in (c) and how did you count them? HOTSEAT Where is the amino terminus of (c) and how do you know? The Beta Sheet: Anti- parallel strands N C HOTSEAT How can you tell if the N and C terminus are correct here? The Beta Sheet: Anti- parallel strands Figure 3-10 TATA-box binding protein Porin Pyrophosphatase Globular Doughnut shaped Butterfly shaped Figure 3-13a Interactions that determine the tertiary structure of proteins Hydrogen bond between side chain and carboxyl oxygen Hydrogen bond between two side chains Hydrophobic interactions (van der Waals interactions) Ionic bond Disulfide bond Figure 3-13b Tertiary structures are diverse. A tertiary structure composed mostly of α-helices A tertiary structure composed mostly of β-pleated sheets A tertiary structure rich in disulfide bonds Figure 3-14-Table 3-3 Figure 3-14 Cro protein, a dimer Hemoglobin, a tetramer Figure 3-20 Substrate (glucose) Enzyme (hexokinase) When the substrate binds to the enzyme’s active site, the enzyme changes shape slightly. This “induced fit” results in tighter binding of the substrate to the active site. “Induced fit” refers to tight binding when the enzyme changes shape upon substrate binding Junctional proteins also have a substrate (often ECM molecules) Figure 41-2 Certhidea olivacea Geospiza magnirostris Geospiza fortis Geospiza fuliginosa Species of Galápagos finch Food source Small seeds Medium seeds Large seeds Insects, nectar An Adaptation: Bird Beaks Another Adaptation: Flocking Behavior In these finches, receptor binding of the peptide hormone, mesotocin, is associated with group size choices. Receptor distributions in bird brains differ in territorial species versus flocking species. Similar peptides also play a role in affiliation choice in mammals and thus may be conserved across evolutionarily distant groups....
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This note was uploaded on 02/21/2010 for the course BIO 131 taught by Professor Paleaz during the Spring '10 term at Purdue.

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1-20-10PeptideHormonePhylogenetics - BIOL13100 Biology II...

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