2-8-10MasterGenes

2-8-10MasterGenes - BIOL13100 Biology II Development...

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Unformatted text preview: BIOL13100 Biology II: Development, Structure, and Function of Organisms February 8, 2010 Dr. Nancy Pelaez Lilly G-224 [email protected] Figure 21-5 Anterior (toward head) Right …are initially established in embryos (such as this mouse). The three body axes observed in humans and other animals… Left Posterior (toward “tail”) Ventral (toward belly) Dorsal (toward back) Posterior (toward “tail”) Dorsal (toward back) Left Ventral (toward belly) Right Anterior (toward head) … also proximal and distal. Master regulators set up the major body axes. Drosophila's set of eight homeobox genes illustrate patterns of embryonic development. A genetic toolkit that determines segmentation dates back to the Cambrian explosion. What triggers differential gene expression? Ch 21 Principles of Development: a) Master Regulators: bicoid mRNA, Bicoid protein b) Chordin and BMP (not detailed in the book) c) Homeotic Genes: Drosophila's set of eight homeobox Molecular differences between species do not simply correlate with differences in appearance. Anterior Posterior Dorsal Ventral The pattern of the Drosophila larva is prefigured by localizations in the egg: http://media.hhmi.org/ibio/short_clips/wieschaus/wieschaus_2.mov What is the nature of the localized substances? Wild type (a) and mutant (b) phenotypes of the bicoid (bcd) gene in Drosophila. Note the duplication of posterior parts and absence of anterior structures in the mutant....
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This note was uploaded on 02/21/2010 for the course BIO 131 taught by Professor Paleaz during the Spring '10 term at Purdue.

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2-8-10MasterGenes - BIOL13100 Biology II Development...

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