StudentLecture_22

StudentLecture_22 - /12/2009 Revised lecture schedule...

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LECTURE 22 11/12/2009 Revised lecture schedule starts today Reading for today & next Tuesday: See “Reading for Lectures 22-23” in the “Reading Assignments and Learning Objectives” folder on Blackboard. Lecture notes. Lab: Preparation of Luminol, Chapter 9 HW as usual this week Exam 3: Thursday, 11/19 at 6:30 pm, Hall of Music. – Reading Assignments and Learning Objectives for Lectures 15-23 on Blackboard – Additional material in Lectures 15-23 – Labs in Chapters 6, 7, 8 See the “Exam III Fa09” folder in the “Exams” folder.
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Oseltamivir is an antiviral drug that slows the spread of influenza (flu) virus between cells in the body by stopping the new virus from chemically cutting ties with its host cell . The drug is sold under the trade name Tamiflu and is taken orally in capsules or a suspension. Tamiflu inhibits Neuraminidase activity This and the following 2 slides contain the images used at the end of lecture 21
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Another Neuraminidase Inhibitor Relenza Tamiflu Note how the central cores of these two molecules are identical: carboxyl group. 6 membered ring with a double bond, amido group para to the carboxyl group
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Neuraminidase is inhibited by drugs such as zanamivir (Tamifu, shown in cyan with the enzyme in green) and oseltamivir (Relenza, shown in pink with enzyme in lemon). The hydrogen bonding of zanamivir is shown. The central core of both drugs fits into the active site of neuraminidase.
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What are the ways we treat cancer? Surgery Physical removal of cancerous tumor Radiation Chemotherapy Destroys all rapidly dividing cells – that includes cancer cells, but also Cells in your hair (hair loss) Bone marrow (fatigue) Stomach lining (nausea) Biologic therapies
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Biologic Therapies for Cancer Treatment Biologic therapies use the immune system to fight cancer or to lessen the side effects of some cancer treatments. interfering with cancer cell growth acting indirectly to help healthy immune cells control cancer helping to repair normal cells damaged by other forms of cancer treatment.
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Understanding Cancer and Related Topics Angiogenesis Developed by: Lewis J. Kleinsmith, Ph.D.
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