StudentLecture_23

StudentLecture_23 - LECTURE 23 11/17/2009 Lab: Models of...

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1 LECTURE 23 11/17/2009 Lab: Models of the Solid State (Ch. 10) HW different, due Wednesday by 12 midnight Exam 3: Thursday, 11/19 at 6:30 pm, Hall of Music. Reading Assignments and Learning Objectives for Lectures 15-23 on Blackboard Additional material in Lectures 15-23 Labs in Chapters 6, 7, 8 See the “Exam III Fa09” folder in the “Exams” folder. 7:00p - 9:00p, Tuesday, 17 November, RHPH 172
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2 Malaria For thousands of years malaria swept through the  ranks of humankind like a scythe in the hands of an  angry god.   Each year, malaria attacks about 400 million people,  two to three million of whom succumb to the illness.    Information Center for Sickle Cell and Thalassemic Disorders Malaria is caused by a parasitic protozoa and is transferred to humans by mosquitos Symptoms: VERY high fever (107°F), chills, nausea, delirium (the high fever cures syphilis)
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3 Malaria Parasites reproduce in the liver then in red blood cells, then in mosquitos who transmit them to another host Parasites
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4 Distribution of  malaria Distribution of  Sickle cell trait  Question #1 Malaria and sickle cell trait are found in the same general  regions of the world because
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5 A Digression, Sickle Cell Trait Normal red  blood cell Sickle cell
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6 mutation
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7 Val-His-Leu-Thr-Pro- ____ -Glu-Lys- Ser…. Val-His-Leu-Thr-Pro- ____ -Glu-Lys- Ser… GAA GTA
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8 Sickle Cell Trait Steelers’ safety Ryan Clark did not play Monday night (11/9/2009) against the Broncos in Denver. Like 1 in 12 black Americans, Clark has sickle-cell trait, which makes it dangerous for him to play at high altitude. At altitude his red blood cells will sickle. Heat, dehydration, altitude and asthma can increase the risk or sickling .  
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9 Back to Malaria Before the arrival of European settlers, Peruvian Indians used bark from the Cinchona tree (found in the Andes) to halt shivering brought on by cold temperatures. Because malaria also causes shivering Cinchona bark was tried with malaria (around 1600) and found to cure malaria. Cinchona bark was harvested (almost to extinction) and sent back to Europe.
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The active ingredient in Cinchona bark is quinine, isolated in 1820. Treatment of Malaria:
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StudentLecture_23 - LECTURE 23 11/17/2009 Lab: Models of...

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