mitochondrial disease

mitochondrial disease - • Neuropathy ataxia retinitis...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Mitochondrial Diseases Diabetes mellitus and deafness (DAD) o this combination at an early age can be due to mitochondrial disease o Diabetes mellitus and deafness can also be found together for other reasons Leber's hereditary optic neuropathy (LHON) o visual loss beginning in young adulthood o Wolff-Parkinson-White syndrome o multiple sclerosis -type disease Leigh syndrome (subacute sclerosing encephalopathy) o after normal development the disease usually begins late in the first year of life, although onset may occur in adulthood o a rapid decline in function occurs and is marked by seizures, altered states of consciousness, dementia, ventilatory failure
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: • Neuropathy, ataxia, retinitis pigmentosa, and ptosis (NARP) o progressive symptoms as described in the acronym o dementia • Myoneurogenic gastrointestinal encephalopathy (MNGIE) o gastrointestinal pseudo-obstruction o neuropathy • Myoclonic Epilepsy with Ragged Red Fibers (MERRF) o progressive myoclonic epilepsy o "Ragged Red Fibers" - clumps of diseased mitochondria accumulate in the subsarcolemmal region of the muscle fiber and appear as "Ragged Red Fibers" when muscle is stained with modified Gomori trichrome stain o short stature o hearing loss o lactic acidosis o exercise intolerance...
View Full Document

This note was uploaded on 02/21/2010 for the course BIO 101 taught by Professor Noidea during the Spring '10 term at 東京国際大学.

Ask a homework question - tutors are online