Lecture Notes - Protein Families • There are estimated to be approximately 24,000 protein-coding human genes • But each one doesn’t begin

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Protein Families • There are estimated to be approximately 24,000 protein-coding human genes • But each one doesn’t begin evolving from one amino acid • Proteins can be classified into many families with a similar linear sequence and conformation • Proteins within families may be products of gene duplications • Advantageous mutations cause proteins within families to deviate from one another over time • These serine proteases are members of a large family of protein-cleaving enzymes • The amino acids in the chain shaded in green are the same in the two proteins • The active site of each enzyme is circled in red • Domain shuffling is another mechanism for creating new proteins • This occurs when the DNA encoding a particular protein domain undergoes a duplication in tandem with another domain • This results in their translated AA’s being linked together in series and forming extended structures This ECM protein contains a series of four different domains •...
View Full Document

This note was uploaded on 02/22/2010 for the course BE 2400 taught by Professor Goldman during the Fall '08 term at Michigan Technological University.

Page1 / 9

Lecture Notes - Protein Families • There are estimated to be approximately 24,000 protein-coding human genes • But each one doesn’t begin

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online