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Lecture Notes 9-19-08 - ProteinFamilies ,000 aminoacid du

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Protein Families There are estimated to be approximately 24,000  protein-coding human genes But each one doesn’t begin evolving from one  amino acid  Proteins can be classified into many families  with a similar linear sequence and conformation Proteins within families may be products of gene  duplications Advantageous mutations cause proteins within  families to deviate from one another over time
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 These serine proteases are members of a large family of protein-cleaving  enzymes  The amino acids in the chain shaded in green are the same in the two proteins • The active site of each enzyme is circled in red
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Domain shuffling is another mechanism for  creating new proteins This occurs when the DNA encoding a  particular protein domain undergoes a  duplication in tandem with another domain  This results in their translated AA’s being  linked together in series and forming  extended structures
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This ECM protein contains a series of  four different domains
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