Lecture Notes 9-22-08 - Aproteinwithone bindingsitecanforma...

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• A protein with one  binding site can form a  dimer with another  protein (A)  This is a  common globular  protein structure  Proteins with two  different binding sites  often form a long  helical filament (B) • Common fibrous  protein structure • If the two binding  sites are disposed  appropriately in  relation to each other,  the protein subunits  may form a closed ring  instead of a helix (C)
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 Two identical protein subunits binding together to form a  symmetric protein dimer  This protein (Figure 3-21) binds to DNA  The subunits are held together by hydrophobic force (blue)  and a set of hydrogen bonds (yellow)
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Ligand Dimer Two identical protein subunits bind  together to form the Tyrosine Kinase  Receptor ligand
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• A protein can interact  with another or multiple  other proteins through  noncovalent  interactions   This protein contains 
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Lecture Notes 9-22-08 - Aproteinwithone bindingsitecanforma...

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