Lecture Notes 9-24-08 - Protein Function Proteins bind to...

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Protein Function Proteins bind to other molecules in a highly selective manner Many weak bonds are needed to enable a protein to bind tightly to a second molecule The ligand must therefore fit precisely into a protein’s binding site so that a large number of noncovalent bonds can be formed between the protein and ligand
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The folding of a polypeptide chain creates a cavity on the protein surface This crevice contains a set of amino acids that can make noncovalent bonds only with specific ligands
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Hydrogen bonds and ionic interactions are formed between a protein and its ligand The surface of each protein molecule has a unique chemical reactivity that depends not only on which amino acid side chains are exposed, but also on their exact orientation relative to one another. Two slightly different conformations of the same protein may differ greatly in their chemistry
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The aspartic acid side chain (Asp 102) induces the histidine (His 57) to remove the proton from
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This note was uploaded on 02/22/2010 for the course BE 2400 taught by Professor Goldman during the Fall '08 term at Michigan Technological University.

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Lecture Notes 9-24-08 - Protein Function Proteins bind to...

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