Lecture Notes 10-06-08 - Cholesterol The cholesterol...

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Cholesterol The cholesterol molecules decrease the permeability properties of the cell membrane The cholesterol molecule inserts itself roughly equally into both layers of the membrane in a similar orientation as the phospholipid molecules the polar head of the cholesterol is aligned with the polar head of a phospholipid The rigid steroid ring of a cholesterol molecule interacts with the first few hydrocarbon groups in the hydrocarbon chain of a neighboring phospholipid molecule, stabilizing and decreasing the mobility of the hydrocarbon chain Cholesterol decreases permeability of the bilayer to small water-soluble molecules
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Lipid movie
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Phospholipids Four types of phospholipids comprise roughly half the mass of lipid in most membranes Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin Important for the proper function of trans membrane proteins Bind to proteins that associate at the cytosolic face of the membrane
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Lecture Notes 10-06-08 - Cholesterol The cholesterol...

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