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Lecture Notes 10-27-08 - Desensitization Movie15.5

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Desensitization  Densensitization resets the response to a stimulus so that cell becomes less  responsive to the same level of signal.    This allows the cell to detect a  change  in a signal strength.
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Movie 15.5
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Some G proteins signal by  regulating the production of the  small intracellular mediator cyclic  AMP (cAMP) The normal concentration of cyclic  AMP inside the cell is about 10 -7   M, but an extracellular signal can  increase this twenty-fold within a  few seconds cAMP is synthesized from ATP by  a plasma-membrane bound  enzyme adenylyl cyclase and it is  rapidly degraded by cyclic AMP  phophodiesterase cAMP concentration is generally  regulated by controling adenylyl  cyclase activity with G s   (stimulatory) or G i  (inhibitory) G  proteins, not by decreasing the  activity of phophodiesterase
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