Lecture Notes 10-29-08 - Signalingthroughenzymelinkedcell...

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Signaling through enzyme-linked cell- surface receptors Enzyme linked receptors are a second major type of cell- surface receptor They are transmembrane proteins generally with one  transmembrane segment They have a ligand binding domain on the outer surface of  the plasma membrane They are activated by signal proteins called growth factors The cytosolic domain has intrinsic enzymatic activity or  associates directly with an enzyme The response to activation is generally on the order of  hours because they require many intracellular signaling  steps leading to changes in gene expression Enzyme-linked receptors also can mediate rapid changes  to the cytoskeleton, regulating cell shape and migration
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Six classes of enzyme-linked receptors have  been identified: 1) Receptor tyrosine kinases  phosphorylate specific  tyrosines on a small set of intracellular signaling 
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This note was uploaded on 02/22/2010 for the course BE 2400 taught by Professor Goldman during the Fall '08 term at Michigan Technological University.

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Lecture Notes 10-29-08 - Signalingthroughenzymelinkedcell...

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