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Lecture Notes 11-17-08 - RNApolymeraseII factors,...

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RNA polymerase II RNA polymerase II requires general transcription  factors, which assemble at the promoter with the  polymerase before transcription begins Transcription factors, termed TFIIA, TFIIB, and  so on, help to: Position the RNA polymerase correctly at the  promoter Aid in pulling apart the two strands of DNA Release RNA polymerase from the promoter into the  elongation mode once transcription has begun
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Assembly process  starts with binding of  TFIID to a short  sequence of DNA in the  gene promoter This DNA sequence is  primarily composed of T  and A nucleotides and  is called the TATA box Transcription Initiation
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 The three- dimensional structure  of TBP (TATA –  binding protein) bound  to DNA at the TATA  box  The DNA bending  caused by TBP may  serve as a landmark  that helps attract other  general transcription  factors
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