Lecture Notes 11-17-08 - RNA polymerase II RNA polymerase...

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Unformatted text preview: RNA polymerase II RNA polymerase II requires general transcription factors, which assemble at the promoter with the polymerase before transcription begins Transcription factors, termed TFIIA, TFIIB, and so on, help to: Position the RNA polymerase correctly at the promoter Aid in pulling apart the two strands of DNA Release RNA polymerase from the promoter into the elongation mode once transcription has begun Assembly process starts with binding of TFIID to a short sequence of DNA in the gene promoter This DNA sequence is primarily composed of T and A nucleotides and is called the TATA box Transcription Initiation The three- dimensional structure of TBP (TATA binding protein) bound to DNA at the TATA box The DNA bending caused by TBP may serve as a landmark that helps attract other general transcription factors...
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This note was uploaded on 02/22/2010 for the course BE 2400 taught by Professor Goldman during the Fall '08 term at Michigan Technological University.

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Lecture Notes 11-17-08 - RNA polymerase II RNA polymerase...

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