Lecture Notes 12-8-08 - Chapter7 ControlofGene Expression...

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Chapter 7 Control of Gene  Expression
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Neuron and Lymphocyte
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Cell Specific Protein Synthesis All organisms begin as a single cell that  develops into all the cells of our body Each cell type has specific functions Some proteins are abundant in specific cells and  are not present in other cell types Because the DNA is not altered during  differentiation (with a few exceptions), all the  different cell types that make up an organism  have identical DNA
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 A differentiated cell contains all the genetic instructions  necessary to direct the formation of a complete organism
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Overview of Gene Control A cell can change the expression of its genes in response  to an external signal Gene expression can be regulated at many of the steps in  the pathway from DNA to RNA to protein By controlling when and how often a given gene is transcribed  (transcriptional control) Controlling how the RNA transcript is spliced or otherwise  processed (RNA processing control) Selecting which completed mRNAs in the cell nucleus are  exported and localized in the cytosol (RNA transport and  localization control) Selecting which mRNAs in the cytoplasm are translated by  ribosomes (translational control)
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Lecture Notes 12-8-08 - Chapter7 ControlofGene Expression...

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