Lecture Notes 12-10-08 - Regulation of Transcription Gene...

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Regulation of Transcription Gene regulatory proteins can act when they bind DNA even thousands of nucleotide pairs away from the promoter that they influence (made possible by DNA looping) Eucaryotic RNA polymerase cannot initiate transcription on its own. It requires general transcription factors, which can be regulated by gene regulatory proteins
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Gene Control Region Gene Control Region refers to the entire portion of DNA involved in regulating transcription of a gene, including the promoter and all regulatory sequences The regulatory sequences (which are bound by regulatory proteins) control the rate of assembly processes at the promoter Of the roughly 25,000 human genes, ~8% (~2000 genes) encode gene regulatory proteins Each gene in a eukaryotic cell is regulated differently from nearly every other gene
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The promoter is the DNA sequence where the general transcription factors and the polymerase assemble The regulatory sequences serve as binding sites for gene regulatory proteins
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Lecture Notes 12-10-08 - Regulation of Transcription Gene...

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