biomaterials 3 - What governs biomaterial choice? The...

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Unformatted text preview: What governs biomaterial choice? The specific application Example problem: One common biomaterial application is the construction of an arterial graft, a device that replaces a section of an artery. What specific material characteristics should be considered for an arterial graft application? Flexibility Tensile Strength Easy to shape Smoothness (surface roughness) Hydrophobicity Non-resorbable bulk surface degradative Important properties of biomaterials: Achieved by material choice and appropriate processing methods 1. Degradation behavior 2. Surface properties 3. Bulk properties Each of which directly affects the biological response and is critical when designing an optimal material for a given application Important properties of biomaterials: Degradation behavior in vivo affected by: 1. Shape, size, location 2. Chemical, physical, mechanical bulk and surface properties 3. Host/inflammatory response Can be undesired or designed response but in both cases: 1. Time before failure is important 2. By-product biocompatibility! Important properties of biomaterials: Surface properties key to protein attachment (adsorption) to material surface in vivo : 1. Surface of a material is defined to be the few atomic layers on the exterior of material 1. Can be distinct from bulk properties-processing or interaction with biologic factors cells/proteins 1. Both physical and chemical in nature: Hydrophobicity (chemical) Surface roughness (physical) Important properties of biomaterials: Bulk properties are often most important in determining suitability of certain materials for specific applications: 1. Smaller role than surface in initial inflammatory response 2. Basic groupings of bulk properties: Mechanical properties : strength, stiffness, fatigue behavior Physical properties : crystallinity, thermal transitions 3. Chemical composition dictates bulk properties Example problem: One common biomaterial application is the construction of an arterial graft, a device that replaces a section of an artery....
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biomaterials 3 - What governs biomaterial choice? The...

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