MCB 102 F08 Lect _7 DRAFT - Announcements None as of 8 PM,...

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Announcements None as of 8 PM, Thurs., 11 Sept.
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Four Levels of Structure in Proteins Primary Structure Secondary Structure Tertiary Structure Quaternary Structure
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Primary Structure of Bovine Pancreatic RNAse A
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Amino Acid Sequence Determines Protein Structure Rapid Dilution Renatured Slow Dialysis (catalytically active) The Anfinsen Experiment urea
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Bond Bond Length (A˚) Bond Strength (Dissoc. Energy) (kJ/mol) C—C 1.54 356 C—N 1.50 292 C—N 1.32 615 S—S 2.06 214 C—O 1.24 730 Importance of covalent bonds (4.184 kJ = 1 kcal) T h e r m So, even at 100˚C, not enough energy to break any covalent bond in a protein
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: Properties of the Peptide Bond Tautomerization (resonance of the lone pair from the amide nitrogen to the carbonyl oxygen allows for greater electron delocalization) gives every peptide bond: (a) a dipole moment (due to the charge separation) (a) planarity (due to the partial double bond character of the amide C—N linkage)
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Polypeptide backbone is a series of planes joined by swivel joints
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This note was uploaded on 02/22/2010 for the course MCB N/A taught by Professor Calendar,thorner during the Fall '08 term at University of California, Berkeley.

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MCB 102 F08 Lect _7 DRAFT - Announcements None as of 8 PM,...

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